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Yes, most cases of loose stools associated with tirzepatide resolve spontaneously as the body adapts to the medication, typically within the first few weeks of treatment or after dose increases
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When combined with adequate protein intake, resistance training can significantly reduce lean tissue losses associated with calorie restriction
This discussion is especially relevant for patients with established atherosclerotic cardiovascular disease (ASCVD), chronic kidney disease (CKD), and obesity-related complications
In our practice, when a patient says semaglutide "stopped working," we look for fixable explanations first: Were you titrated to an effective dose, or stuck low because of side effects
For some people, the small bowel then moves contents faster or in an uncoordinated way, which produces loose stools rather than constipation
However, like semaglutide, retatrutide's effect on stomach emptying lessens over time, which might need a break from the drug to restore its effectiveness
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