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Researchers who have struggled with tirzepatide losing effectiveness over time might consider whether switching to CagriSema when it becomes available could reignite weight loss through the different amylin-based mechanism

The glycolysis modulator TIGAR, a fructose-2,6-bisphosphatase (Fru-2,6-BP), also plays a key role in the modulation of metabolism in response to oxidative stress

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