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Accumulating evidence indicates that enteric neurons modulate immune cell distribution and function within the intestinal wall primarily through cytokine-mediated neuro-immune signaling, influencing macrophages, dendritic cells and lymphocytes 11,12,13

A range of studies back up this FDA-approved formulas efficacy

Cochrane file, two of them

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Both of these medications have similar safety profiles, but they work in slightly different ways