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In an animal high-altitude model, phosphorylated DSIP improved spatial-memory and sleep-architecture markers, but sample size was not clearly reported and this was not a healthy-human trial [11]

In an embodiment, the pH is adjusted using a base to facilitate dissolution in the buffer solution

In addition, reported outcomes are contextualized according to their nature, whether subjective (e.g., sleep quality, self-reported symptoms), physiological (e.g., circadian phase markers, metabolic parameters), or biochemical (e.g., oxidative stress markers, inflammatory mediators)

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