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Unlike tirzepatide, which activates both GLP-1 and GIP receptors, MariTide is a GIPR antagonist antibody/GLP-1R peptide agonist conjugate which means that it activates GLP-1 receptors while blocking GIP responses

Every case from arm I was matched for gender, age (1 year range was allowed between the selected patients), and BMI Z score (1 SD range was allowed between them) with a patient from arm II to serve as controls

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S-adenosylmethionine (SAMe) for neuropsychiatric disorders: A clinician-oriented review of research

doi:10.1016/j.biopha.2019.01.041 229

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