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*Correspondence: Susana Fiorentino, [email protected] Disclaimer All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers
doi:10.1080/07315724.1997.10718655
Presented for research literature review only Smith GJ et al
191 For instance, WEE1 inhibition (e.g., with AZD1775) abrogates G2/M checkpoints, thereby potentiating the cytotoxicity of DNA-damaging agents such as cisplatin
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Pharmacokinetic analysis revealed it to be orally active with significantly increased metabolic stability, exhibiting a plasma half-life of 335.5 minutes, allowing for prolonged systemic availability [2]
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