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However, a major limitation of macrophage-reprogramming strategies lies in the extreme plasticity of TAMs and high tumor heterogeneity, which can cause reprogrammed M1 macrophages to revert to an M2 state

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Arthritis Rheumatol 76(2024)

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Glucagon-like peptide (GLP)-1(9-36)amide-mediated cytoprotection is blocked by exendin(9-39) yet does not require the known GLP-1 receptor

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