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FDA Approves 2 Oral Gonorrhea Drugs: What You Need to Know The FDA approved two groundbreaking oral gonorrhea drugs in December 2025Nuzolvence (zoliflodacin) and Blujepa (gepotidacin)offering the first convenient, pill-based alternatives to painful injections for treating this increasingly drug-resistant sexually transmitted infection. Sarah Martinez, a 28-year-old from Austin, Texas, remembers the embarrassment and discomfort of her gonorrhea diagnosis two years ago