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5-Amino-1MQ (5-amino-1-methylquinolinium) is a small-molecule selective inhibitor of nicotinamide N-methyltransferase (NNMT) developed at the University of Texas Medical Branch by Neelakantan and colleagues as part of a medicinal-chemistry program targeting NNMT for metabolic-disease research
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Cagrilintide is a long-acting acylated amylin analogue, a dual amylin and calcitonin receptor agonist that hits the AMY1, AMY2 and AMY3 receptor complexes plus the calcitonin receptor, mainly in the area postrema and hindbrain
Research has shown that it interacts with a number of physiological processes within the central nervous system
Tricellulin forms a barrier to macromolecules in tricellular tight junctions without affecting ion permeability
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