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GLP-1R agonists and SGLT-2 inhibitors are promising tools in our therapeutic armamentarium in this setting [111113] (Figure 1)
35 Biguanides: Metformin reduces the FPG and A1C and has been proven to be safe by trial evidence, showing only mild gastrointestinal (GI) effects and no serious adverse effects
Central venous access is preferred for cumulative dosing above 20 g to avoid phlebitis, and continuous electrocardiography, non-invasive blood-pressure, and pulse-oximetry are minimum monitoring standards throughout and for at least 30 minutes after infusion
Dosing Phases & Cycling The research protocol is typically staged rather than started at full pace, and it is cycled the compound is not framed for indefinite continuous use
Probiotics as potential antioxidants: a systematic review
& Mimic-Oka, J
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