Qiankehe Basic Research-ZK[2024] General 384
What GHK-Cu adds to the formulation: Gene expression modulation across hundreds of genes including collagen genes (Type I, III), tissue inhibitors of metalloproteinases, anti-inflammatory mediators Collagen synthesis stimulation, specifically Type I and Type III collagen the structural proteins of skin, connective tissue, and many other tissues Anti-inflammatory signaling through investigated effects on TNF-, IL-6, and NF-B pathways Copper-peptide chemistry effects including cofactor activity for skin-relevant enzymes Skin-research and hair-research applications (the GHK-Cu literature in these areas is substantial) For the GHK-Cu deep-dive, see Copper Peptides Explained
Unfortunately, Borchel et al
Formulations containing less than 20% w/v HP-B-CD all gave rise to only mild or minimal subcutaneous necrosis at the injection site
In the only published head-to-head study, GHK-Cu supported improved collagen production in 70% of subjects versus 40% for tretinoin
The amino acids glutamine and NAC (along with the help of zinc) can be helpful in reducing gut inflammation, restoring intestinal health, and repairing the tight junction integrity of the gut lining
