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In order to prevent this phenomenon, catalase (another antioxidant enzyme) which is abundant in the peroxisomes breaks down H2O2 into water and molecular oxygen, consequently curtailing free radical-induced damage (Fig
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In this scenario, as juveniles are exposed to physical, chemical, and biological factors, tissue ischemia may neutralize the cofactors of antioxidant enzymes, such as superoxide dismutase and NADPH oxidase myeloperoxidase, preventing return to the body homeostasis (Camini et al
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All cellular macromolecules are susceptible to oxidative harm
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