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Ann Thorac Surg 107(3):936-940, 2019
[...] Even though the carboxylic acid valproate (VPA) is an HDACi with weak inhibitory potential, it is an interesting drug for clinical trials due to its well-characterized pharmacodynamic and pharmacokinetic profile (see Table 6)
Dual agonism may blunt some compensatory mechanisms by targeting multiple points in energy balance regulation
For those primarily concerned with scale weight and metabolic health markers, monotherapy may suffice
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