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Morning administration in older populations produces minimal GH elevation due to compounding factors: lower pituitary GH stores, higher basal somatostatin tone, and reduced receptor density

Phase III results for retatrutide are set to be released later in 2025 and in early 2026, but an earlier phase II trial recorded between a 7.2% and 17.5% reduction in body weight after 24 weeks, depending on the dose (7.2% on 1mg, 17.5% on 12mg), and up to a 24.2% reduction in body weight after 48 weeks for those on 12mg (-8.7% change for those on 1mg) 8

Nutrition Research, 2010

Also, GLP-1 RA seems to regulate glucose homeostasis by exhibiting glucagonostatic effects meaning suppression of glucagon by acting on pancreatic cells, which in turn reduce hepatic production of glucose (52)

Confirmatory large-scale trials are essential to ascertain the potential efficacy of GLP-1RAs in specifically improving the stroke outcomes