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There are a few health conditions and factors that can lead to a Vitamin B12 or folate deficiency

Pumford et al

demonstrated that erastin-induced ferroptosis elevated lysosome-associated membrane protein 2a (LAMP2a) expression and promoted chaperone-mediated autophagy (CMA) while facilitating GPX4 degradation, suggesting a possible connection between autophagy and ferroptosis (Wu et al., 2019)

In addition, skin psoriasis, an anti-TNF--related paradoxical adverse reaction [84], was proven to be induced also by other biologic agents used in IMIDs [85]

Statistical analysis The results are expressed as mean SEM

System X(c) (-)/GSH/GPX4 axis: an important antioxidant system for the ferroptosis in drug-resistant solid tumor therapy