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3.3 Insulin resistance (HOMA-IR, TyG index) and beta cell function indices Linagliptin resulted in a reduction of HOMA-IR in the high GLP-1 prediabetes subjects, albeit not significant

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Some users mention sensitivity to vitamin E as a concern, causing occasional breakouts

Report persistent gastrointestinal symptoms to your healthcare provider, as antiemetic medications or dose adjustments may improve tolerability

A post hoc subgroup analysis also suggested a more pronounced effect with semaglutide, although this finding should be interpreted with caution as hypothesis-generating rather than evidence of superiority

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