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Structural defects underlying protein dysfunction in human glucose-6-phosphate dehydrogenase A() deficiency
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however, EAS enzymes are deactivated due to chronic elevated H 2 O 2 induced by defective mitochondria (Schallreuter, 2014)
Su equilibrio dinmico con la forma oxidada (GSSG), conocido como relacin GSH/GSSG , refleja el estado redox global de la clula y su capacidad de adaptacin frente al estrs metablico.En condiciones fisiolgicas normales, la mayor parte del glutatin se mantiene en su forma reducida, protegiendo protenas, lpidos y ADN frente a la oxidacin