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Hepatic fat accumulation correlates closely with visceral fat deposits, and the mechanisms that clear one tend to clear the other

Increased Glucagon Release: Unlike GLP-1, GIP increases the release of glucagon in a glucose-dependent manner

LCACs also perturb Ca 2+ homeostasis in the cytoplasm and have been shown to disrupt myocardial contractility and electrophysiology, thereby inducing cardiomyopathy and arrhythmias [294]

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But this is anecdotal, and selection bias, those willing to try a newer, less proven compound tend to be more experienced and disciplined, could account for better reported outcomes