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Glutathione takes another route, however, and helps fight free radicals, thereby reducing oxidative stress

Discussion While it is well accepted that EtOH-associated oxidative stress is a key mediator in the pathogenesis of ALD, the molecular details governing this process remain incompletely understood

Spinocerebellar ataxia type 2 Spinocerebellar ataxia type 2a genetic neurodegenerative disorder due to a CAG repeat expansion mutation in the ATXN2 gene coding for the protein ataxin-2 63 has been associated to oxidative stress, in particular due to alterations in the enzymatic activity of antioxidant enzymes including GSTs 64

These non-natural residues contribute to the compound's binding selectivity and resistance to enzymatic degradation

Vanden Broucke, H

: investigation and methodology