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In hypertension, GLP-1 attenuates the excitability of carotid body cells diminishing sympathetic activation, augments renal blood flow to promote natriuresis and diuresis as well as facilitates generation of nitric oxide in vascular smooth muscle cells

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Occasional nausea has been reported, especially when taking the compound without food

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Antibiotics were added to the final concentrations indicated, and cultures were re-incubated with shaking at 300 rpm at 37 C