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Materials and methods Experimental design Thirty-six experimentally nave rats, male, Wistar strain, 3-4 months old, weighing 193 12 g at the beginning of the experiment, were used as subjects

Translating animal doses to human equivalents requires consideration of species-specific pharmacokinetic differences

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Tirzepatide is a dual-action medication that activates both GLP-1 and GIP receptors, working through two hormonal pathways instead of just one

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However, native GLP-1 has a very short half-life of approximately two minutes due to rapid degradation by the enzyme dipeptidyl peptidase-4 (DPP-4)