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In studies using human fibroblast senescence models, the contents of the product were dissolved and added to the culture system at various concentrations

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In animal studies, inhibiting NNMT has been associated with altered energy handling in fat cells and with preserved SAM and NAD availability

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If inhibiting NAD+ synthesis has an adverse effect on 5-amino-1MQs muscle-enhancing effects, this would show that, indeed, the compound likely works through increasing NAD+ levels