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This surge is driven by the recognition that cellular senescence is a stress adaptation
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Prolyl-isomerase Pin1 accumulates in Lewy bodies of Parkinson disease and facilitates formation of -synuclein inclusions
This is especially true for collagen and antioxidants
The clinical implication is that for children showing signs of mitochondrial weakness (low energy, post-exertional fatigue, regression with illness, abnormal organic acids markers, or borderline-low free carnitine on plasma testing), L-carnitine supplementation can be a meaningful adjunct
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