[ 9 , 10 ] These conflicting results highlight the uncertainty that persists in this area of research
SOD activity in diabetes is reduced due to the glycation of the enzyme, which leads to an accumulation of superoxide radicals and oxidative stress
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RNA expression profiling also showed a significant increase in CDKN1A (p21), a p53 target gene coding for a cell cycle inhibitor, together with a decrease in the transcription of CCND1 , CCNE1 and Myc