glp 1 growth Lilly is now pharma's top revenue company. It just got FDA approval for an oral GLP-1, but Wall Street isn't celebrating GLP-1 Receptor Agonist Market Size

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Researchers theorize this may be because: GIP activation may counterbalance some GLP-1 effects on the gut Dose escalation schedule allows more gradual adaptation Different pharmacokinetic profile may produce less pronounced peaks Serious Side Effects (Both Medications): These are rare but require immediate medical attention: Pancreatitis: Severe abdominal pain that may radiate to the back Risk: Less than 1% with both medications Usually occurs in first few months of treatment Requires immediate discontinuation if suspected Gallbladder Problems: Gallstones, cholecystitis (gallbladder inflammation) Symptoms: Right upper abdominal pain, nausea, fever More common with rapid weight loss May require surgical intervention Kidney Problems: Dehydration from vomiting/diarrhea can affect kidney function Watch for decreased urination, swelling in legs Stay well-hydrated, especially during side effect periods Thyroid Tumors (Black Box Warning): Both medications carry warnings about thyroid C-cell tumors Based on rodent studies

From the reconstitution table above: a 5mg vial in 2.5mL of bacteriostatic water gives 2mg/mL

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Guest co-host Sheinelle Jones was curious to know if microdosing a GLP-1 drug was enough for Cohen to make progress in his weight-loss journey

Results The number of human genes associated with stem cell function was 57 genes in the range of increases of 50% UP and 46 genes in the range of decreases of 50% DOWN