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In cell culture assays and preclinical animal models, minute endotoxin contamination can trigger non-specific inflammatory signaling pathways, altering cytokine release, cell viability, and gene expression profiles
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[21] Neurological symptoms: Sensory or motor deficiencies (absent reflexes, diminished vibration or soft touch sensation), subacute combined degeneration of spinal cord, or seizures
[14] [15] It is important to note that routine B12 screening is not currently standard practice for all patients taking GLP-1 receptor agonists, but individualised assessment based on risk factors and symptoms is appropriate clinical practice
Understanding the specific effects reported helps set realistic expectations and allows for informed monitoring during treatment protocols
Carmel, R
