crohn's disease and glp-1 GLP-1RAs for IBD Frontiers | GLP-1 receptor agonists

PMID: 35 ZhengZZongYMaYTianYPangYZhangCet al

They work through different receptor pathways (amylin and GLP-1 respectively) and are injected separately at different sites on the same day

Preliminary findings also suggest improvement in symptoms of chronic fatigue syndrome (22) and physical performance in patients undergoing dialysis for end-stage renal disease (9) , but data on benefits against fatigue associated with multiple sclerosis are inconclusive (21)

Patients with pre-existing gastroparesis, significant gastrointestinal disease, or previous gastric surgery require particularly careful monitoring and may benefit from gastroenterology consultation before initiating GLP-1 agonist therapy

KidaKInoueTKainoYGotoYIkeuchiMItoTet al

Effects of Bitter Substances on GI Function, Energy Intake and Glycaemia-Do Preclinical Findings Translate to Outcomes in Humans