This is because issues with regular function of the gastrointestinal tract can prevent the proper release and absorption of the vitamin, which can cause a deficiency if not supplemented properly
Decreased glutathione levels, ROS accumulation, and increased inflammatory cytokines trigger follicular cell damage, apoptosis, and an autoimmune response (Lopes et al., 2022)
It should be noted, however, that ALDH1A1, but not CYP2E1, is a downstream target of NRF2, which was found to be activated in untreated GCLM KO mouse liver
It could manifest as worsening B12 deficiency symptoms like skin rashes, tingling sensations, burning pain, tremors, heart palpitations, joint pain, and more
Melatonin ameliorates trimethyltin chloride-induced cardiotoxicity: the role of nuclear xenobiotic metabolism and Keap1-Nrf2/ARE axis-mediated pyroptosis
16, 2011, pp