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But changes are happening at the follicular level

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Prone to chronic kidney stones (as high doses of Vitamin C can trigger stone formation)

Higher doses, such as 15 mg/d, have also been tested in short-term studies, though these did not significantly increase plasma spermidine levels owing to pre-systemic conversion into other polyamines, such as spermine (Reference Senekowitsch, Wietkamp and Grimm20)

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This initial dosage, while not effective for glycemic control, is crucial for treatment initiation