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Dose Range: 5001000 mcg daily with gradual titration (~5 mg/week average)

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There is also the question of "non-responders." While tirzepatide has a very high success rate in metabolic research, a small percentage of subjects do not reach the desired benchmarks

Chee WSS, Gilcharan Singh HK, Hamdy O et al (2017) Structured lifestyle intervention based on a trans-cultural diabetes-specific nutrition algorithm (tDNA) in individuals with type 2 diabetes: a randomized controlled trial