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In Cohort 1, 25 WT and 25 RAMP1/3 KO male mice aged 1220 weeks old were injected intraperitoneally after a 12-hour fast with vehicle, sCT at doses of 3 or 150 nmol/kg, or Cagrilintide at a dose of3 nmol/kg

however, the addition of exogenous TRAIL to b-AP15 significantly reduced cell viability in each cell line when compared with b-AP15 alone (dark red line)

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