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We found here that agonist trafficking properties, as well as insulin secretion, mirrored -arrestin recruitment propensity, contrasting with some 14,33 (but not all 34 ) previous work suggesting that -arrestins do not impact GLP-1R trafficking 14,34,35 , as well as reports of coupling of GLP-1R to insulin secretion via -arrestin-1 14 (although not -arrestin-2 60 )
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Clinical trial data shows a safety profile consistent with injectable semaglutide
Lundgren JR et al
[7] DCT converts dopachrome to DHICA during the eumelanin pathway
doi: 10.1002/med.21431 263
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