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1.3.9 Heparanase and calcium Heparanase, an enzyme that cleaves heparan sulfate proteoglycans, has been implicated in various pathological processes, including endothelial damage (Rops et al., 2004
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(PubMed) de Menezes Barbosa EG, Junior FB, Machado AA, Navarro AM
These effects may potentially provide a novel therapeutic solution for stroke, imparting specific beneficial effects on the CNS (i.e., for reperfusion, the amelioration of neuronal damage and, thereby, recovery without memory, locomotor, and coordination disturbances, and the expression of the particular genes in the hippocampus)
Future Directions and Emerging Research The next stage of AHK-Cu research will probably combine materials science, computer modeling, and chemistry
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