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3,4 Some people with eating disorders or patterns of disordered eating may misuse semaglutide (and other weight loss medications) for weight management since this medication can reduce appetite and caloric intake

However, other studies have indicated that POMC GLP-1R knockdown can increase HFD-induced weight gain, and ARC GLP-1R blockade by GLP-1R antagonists attenuated the anorexic effects of liraglutide [57]

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