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References Gumpricht E and Varady KA: Health effects and weight loss benefits of calorie restriction dietary regimens

This results in the closure of ATP-sensitive potassium (K ATP ) channels, which in turn leads to cell depolarization, the opening of voltage-dependent Ca 2 channels (VDCCs), and the subsequent influx of Ca 2

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These side effects may lead some individuals to drink less fluid

In addition, protein ingestion in close temporal proximity to resistance exercise appears to further potentiate hypertrophic adaptations, particularly in older adults

While outcomes remain speculative, the mechanistic parallels continue to stimulate new investigative questions