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The "LR3" modification (a substitution at position 3 and an arginine extension) reduces IGF-1 LR3's affinity for IGF-binding proteins (IGFBPs)
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doi: 10.7554/eLife.62199 60 SteinbergD.ParthasarathyS.CarewT.KhooJ.WitztumJ
doi:10.1038/s41467-025-58680-y Carvas AO, Leuthardt A, Kulka P, et al
With respect to reversibility, mild or single episodes of heat stress usually cause only a transient decline in sperm quality, which can recover after one to two spermatogenic cycles (Rao et al., 2015)
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