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Rather than developing another pure GLP-1 agonist, Lilly pursued a dual-mechanism approach targeting both GLP-1 and GIP (glucose-dependent insulinotropic polypeptide) receptors

GI events were the most common adverse effects, with the vast majority being mild to moderate in severity

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While effective, they require needles, refrigeration, and self-injection, which can be inconvenient or uncomfortable for some patients