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Silva, L

Instead of finishing every crumb on their plate, they notice fullness earlier

( Epub 20200229 )

The reduction in Agt and AT1a expression implies a suppression of Angiotensin II (Ang II) activity, which is hypothesized to contribute to fibrosis.This hypothesis seems plausible as angiotensin receptor blockers and ACE inhibitors have long been studied for their potential to slow down cardiac modeling/fibrosis and researchers suggest they are first line of prevention for fibrosis

Across all STEP trials, the consistent finding was 14.9% to 17.4% average body weight reduction at 68 weeks with the 2.4 mg dose