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A PBM earning a large rebate on Humira has a direct financial reason to keep Humira on the preferred formulary, even when the biosimilar costs the plan less on a net basis
It has been shown to result in loss of 3% body weight at 3 months and 5-7% body weight loss after 6 months
The expression of pro-inflammatory mediators, including interleukin-1 (IL-1), IL-6, and tumor necrosis factor (TNF-), increase in cartilage, bone, and synovium, contributing to the initiation of OA 4,5
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