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Under hyperglycemic conditions, SGLT2-dependent SGK1 activation drives canonical tubular epithelial cell pyroptosis, as confirmed by GSDMD-mediated pore formation and the release of IL-1, IL-18, and LDH (167)
While NAC can be taken as an oral supplement, an oral solution can also be composed by specialty pharmacies and used in a nebulizer machine
Nutrients 14 (18), 3723
Adequate GSH levels help preserve neuronal integrity, while depletion is a hallmark of neurodegenerative diseases such as Parkinsons and Alzheimers (4849)
Nature 530 , 447 (2016)
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