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William Blair may or may not own any securities of the issuers referenced and, if such securities are owned, no representation is being made that such securities will continue to be held

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Glucagon-like peptide-1 and its receptor agonist exendin-4 modulate cholangiocyte adaptive response to cholestasis

Knowing how to manage them helps you stay comfortable: For nausea and digestive discomfort: Eat smaller, more frequent meals Avoid greasy, spicy, or highly processed foods Stay well hydrated (aim for 2-3 litres daily) Try ginger tea or peppermint tea Avoid lying down immediately after eating For fatigue: Ensure adequate protein intake at every meal Prioritise 7-8 hours of sleep Stay hydrated throughout the day Consider light exercise to boost energy For injection site reactions: Rotate injection sites each week Allow medication to reach room temperature before injecting Apply ice before injection if needed In clinical trials, approximately 20-30% of participants experienced mild side effects during the first month, with most improving significantly by week 4 1