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whereas, IH LATE reduced the proportion of birth-dated neurons

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Indeed, glucose hypometabolism is present in both early and advanced stages of ADRD with greater impairments in metabolism coinciding with worsening neurodegeneration (Desgranges et al., 1998

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Moreover, astrocytes contribute to lipid and ketone metabolism, playing a role in fatty acid oxidation, which supplies up to 20% of the adult brains energy needs 35