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Retatrutide (LY3437943) is a novel synthetic peptide developed by Eli Lilly and Company

One sample did not have full villi lengths and was therefore excluded from the Fig

For reconstitution, adding 1.0 mL creates a 10mg/mL concentration (100 units for a 10mg dose in a single injection)

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Studies have shown that retatrutide maintains common interactions with conserved residues across the three receptors while also accommodating receptor-specific interactions that enhance its binding affinity and efficacy