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Both use a gradual dose escalation to minimize GI side effects, sharing the same schedule through 1.0 mg before diverging

For instance, in vitro studies demonstrated that mitochondrial respiratory chain dysfunction, induced by exogenous inhibitors of Complex I (rotenone) and Complex II (3-nitropropionic acid), was alleviated by KBs [59]

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Further investigation using in situ hybridization revealed DPP-4 expression in the osteoclast lineage

There is no combination-level human data a genuine evidence gap that this guide does not paper over