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Ingested -carotene can be cleaved in the lumen of the intestine by either of two -carotene oxygenases (-carotene-15,15-monooxygenases) encoded by the BCO1 and BCO2 genes to yield two molecules of retinaldehyde (retinal)

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293 Multiple miRNAs modulate cisplatin resistance in bladder cancer by targeting critical pathways such as AKT/mTOR, JAK/STAT, Wnt/-catenin, and p53, thereby regulating proliferation, apoptosis, autophagy, and glutathione metabolism