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While GLP-1 receptors exist in brain regions associated with mood and reward, serious mood disturbances are uncommon and should be reported to a provider if they occur

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While strict biweekly (14-day) dosing is occasionally discussed, more users mention experimenting with 10-11 day intervals as a compromise between cost savings and maintaining effectiveness

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Search strategy A systematic search was conducted across various databases and registers, including MEDLINE (via PubMed), Scopus, Cochrane Central Register, and ClinicalTrials.gov