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Medications like semaglutide and tirzepatide mimic this natural hormone but in a much more powerful and long-lasting way

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2024 Apr 4;390(13):1176-1185

A prespecified analysis of SELECT, a trial in people with overweight or obesity and CV disease but without diabetes, found that semaglutide reduced MACE across adiposity groups, with reductions in waist circumference only partially mediating the observed benefit [32]

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