Reversible phosphorylation of the SOD1 residue Ser39 in yeast and Thr40 in human cell lines (HEK293, Hep3B, A549, and MCF7 cell) by mTOR signaling moderates ROS levels, prevents oxidative damage, and regulates redox-dependent growth and survival (Tsang and Zheng, 2018
Fasting is a risk factor, possibly because of depletion of hepatic glutathione reserves
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There are several processes that contribute to mitochondrial quality control, including UPR mt , mitophagy, mitochondrial membrane dynamics, and mitochondrial biogenesis 13,89
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