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ANG1005, ANG conjugated to paclitaxel (PTX), has previously been investigated in clinical trials for malignant glioma recurrence [116]

One should consider the primary phase lesion and hemorrhaging that results from mechanical damage during SCI as well as the secondary phase lesion that lasts several hours or even several months and is accompanied by edema, hemorrhage, inflammation, and cytotoxic edema [44,45,46,47] and may extend to the white matter area and lead to white matter degeneration and damage [48, 49]

Importantly, 1015% of global population have an inherited condition of limited riboflavin absorption and utilization