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The NOAEL indicates the highest dose tested that produced no adverse effects, but it does not account for species-specific differences in NNMT biology or long-term human metabolic responses

Every cell relies on energy to maintain function, adapt to changing conditions, and respond to environmental demands

This does not invalidate the findings, but it is a standard scientific quality consideration that most pages omit

S., Wan, T

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The key word is "may" because the downstream consequence of receptor upregulation is not the same as receptor activation, and human receptor expression studies have not been published